Healthcare

8:30 - 10:30 Tuesday 23 September
Chair: Byron Lambert- Abbott Vascular, USA

11:00 - 12:30 Tuesday 23 September
Chair: Byron Lambert

11:00 - 12:30 Wednesday 24 September
Chair - Arne Miller, RisØ National Laboratory, Denmark

8:40 - 9:05 Wednesday 24 September | Healthcare 3: Process Monitoring

Marc F. Desrosiers, National Institute of Standards and Technology, USA | NIST developed the alanine dosimetry system in the early 1990's to replace radiochromic dye film dosimeters. Later in the decade the alanine system was firmly established as a transfer service for high-dose radiation dosimetry and an integral part of the internal calibration scheme supporting these services.

9:05 - 9:30 Wednesday 24 September | Healthcare 3: Process Monitoring
Mark Bailey, National Physical Laboratory, UK | The dose rate distribution in a MDS Nordion JS7500 60Co industrial irradiation plant has been calculated using the EGSpp Monte Carlo code. This code is a development of the established EGSnrc code developed and distributed by National Research Council of Canada.

9:30 - 9:50 Wednesday 24 September | Healthcare 3: Process Monitoring
Kevin O'Hara, Canada | Absorbed-dose calculations provide insight into the critical areas for dose mapping and routine monitoring, allowing for the optimal placement of dosimeters. Accessible, accurate and validated dose-calculation programs can be used to help optimize the radiation process and reduce the requirement for dosimetry.

9:50 - 10:10 Wednesday 24 September | Healthcare 3: Process Monitoring

Peter Veselovsky: Konnexis Inc., Canada | In an incremental carrier irradiator with product interchange located outside of the biological shield and "shuffle and dwell" source pass mechanism it is difficult to predict product mix inside the source pass at any given time. Cycle time setting is limited to a fixed time value that translates to a fixed dose per pass of around 2.5 kGy to allow processing of small product batches with varying dose requirement.

11:00 - 12:30 Wednesday 24 September
Chair - Arne Miller, RisØ National Laboratory, Denmark

11:00 - 11:25 Wednesday 24 September | Healthcare 4: Process and Technology
Dieter Bachmann, Cilag AG, Switzerland | Low-energy electron beam technologies are being used as an effective means to decontaminate materials for use in aseptic filling applications. To date, this technology has been applied most successfully to decontaminate the outer surfaces of containers housing pre-sterilized syringes used in aseptic filling isolators.

11:25 - 11:50 Wednesday 24 September | Healthcare 4: Process and Technology
Jakob Helt-Hansen,Risø National Laboratory, Denmark | Irradiation with low-energy electrons (100 - 300 keV) results in dose gradients across the thickness of the dosimeters typically used for dose measurement at these energies. This leads to different doses being measured with different thickness dosimeters irradiated at the same beam. In order to overcome this problem a new concept is introduced of correcting all measured doses to the mean dose in the first micron - Dµ.

11:50 - 12:15 Wednesday 24 September | Healthcare 4: Process and Technology
Smith, Mark, Sterigenics, USA | The standard on radiation sterilization of medical products (International Standards Organization ISO 11137-1, Sterilization of health care products - Radiation- Part 1: Requirements for the development, validation and routine control of a sterilization process of medical devices. (2006)) states, "If energy for electrons exceeds 10 MeV...the potential for induced radioactivity in product shall be assessed."

Poster Sessions IMRP 2008 London Tuesday 23 September 13:30 - 15:00
Poster Presenters will be allocated their Poster Space when they register at the Programme Registration Desk in the Hotel Lobby.

Ordered by Reference Number (Date Received).

Fairand, Barry P. USA | Pharmaceuticals as a class are more sensitive to radiation than medical devices. Radiation sterilization of drug products at low doses to achieve an SAL of 10-6 would be beneficial. A method was developed for radiation sterilization of extremely low bioburden products at doses much less than 10 kGy. The method does not require the sacrifice of a large number of test samples. One potential application would be sterilization of aseptically manufactured pharmaceutical products following a fill/finish operation.

Lundahl, Brad USA | A poster presentation shall address the impact of irradiation environment parameters, specifically dose rate and temperature of gamma irradiation on the functional characteristics of several selected ompounds. As a secondary permutation, the compounds will be presented both a liquid and dry formats thus providing a 2 x 2 permutation matrix of irradiation environmental formats and compound formats.

Farah, K. et. al., Tunisia | During the last decades sugar was considered as a promising radiation sensitive material and used as a radiation detector for high level dosimetry by applying different analytical methods especially for the solid state/EPR dosimetry. This method is high cost and suggested only for reference dosimetry.

Jeong, Il Yun et. al., Korea | Skin contact allergy (SCA) is not life-threatening, but a large number of people suffer from the reactions caused by various kinds of chemicals and products. Thus, radiation technology was employed to improve the traditional herb addition method on the SCA reduction of Rhus verniciflua sap. R. verniciflua has traditionally been used as an herbal medicine plant, but its urushiol derivatives are known as a major allergen for the SCA.

GARCIA, Tristan et. al., France | The Laboratoire National Henri Becquerel uses ESR spectrometry to ensure high dose traceability (100 Gy - 100 000 Gy) for industrial applications involving radiation processing. Furthermore, free radical detection by ESR spectrometry could provide helpful information on drugs stability for pharmaceutics industry. Indeed, free radicals created during irradiations induce chemical reactions.

Garcia, R. et. al., USA | Response functions for Radiachromic Film Dosimeters used to measure delivered dose in Electron Beam processing have historically been developed in-situ.

Kim, Jae-Hun et. al., Korea | Doxorubicin (DOX) is widely used as an anticancer agent, but has given some problems with the immunological toxicity to patients during chemotherapy. The present study was conducted to evaluate the effect of gamma irradiation on the immunological toxicity and cytotoxicity of DOX.

Byun, Eui-Baek et. al., Korea | The physicochemical properties of proteins can be altered by irradiation. But, it is rarely that the researches on the functional properties of irradiated proteins have been reported. Fibroin is a fibrous protein derived from silkworm Bombyx mori and has been suggested as a biomaterial for biomedical applications.

Sung, Nak-Yun et. al, Korea | β-glucans are structural cell wall polymers of many microorganisms and cereals which possess immunomodulatory properties and have been used in the food, cosmetic and medical industry. In our previous study, β-glucan was depolymerized by gamma irradiation and thus lead to improve the solubility and viscosity.

Takehisa, Masaaki et. al., Japan | The measurable dose range of 0.1 to 50 kGy can be covered using different type of conventional PMMA dosimeters. Novel PMMA dosimeter (Radix W), which is manufactured based on chemical cross linkage, was developed to cover wider dynamic dose range of 2 to 150 kGy employing different readout wavelengths of 280nm and 320nm for dose range up to 10 kGy and higher, respectively.

Boardman, Jeffery et. al., U.K. | Jeffery Boardman (Amos Ltd) has developed very robust, cost effective and simple to operate radiation detectors over the past 5 years.

FONTCUBERTA, Philippe et. al., France | A self-shielded sterilisation system using electron beam has been developed for complete and/or terminal sterilisation of products. The system contains a medium energy accelerator (5 MeV, 5 kW), conveyor and ancillary equipment built inside a stainless steel housing designed for installation in a production line.

Sharpe, P.H.G., et. al., U.K, | Published data on the effect of irradiation temperature on the response of alanine dosimeters does not extend to the temperatures that may be experienced in high dose industrial irradiations, particularly in the case of electron beams. We describe here results of the irradiation of alanine dosimeters at temperatures up to 80 ºC and doses up to 100 kGy.

Lim, Youn-Mook et. al., Korea | Atopic dermatitis (AD) is a familial and chronic inflammatory pruritic skin disease that affects a large number of children and adults in industrialized countries. It is known that one of prominent features of AD and chronic pruritus is partially due to the histamine released from mast cell. In this work, hydrogel patches with natural herbal extracts were prepared by "a freezing and a thawing", and a gamma irradiation.

Gwon, Hui-Jeong et. al., Korea | The objective of the present study was to investigate the enhanced adsorption property of a PVA/glycerine hydrogels, as compared to the previously prepared hydrogels with a k-carrageenan for a wound dressing, which were prepared by using a gamma irradiation.

Youn, Min-Ho et. al., Korea | In order to synthesize β-tricalcium phosphate (β-TCP), a mixture of Ca(OH)2 and H3PO4 was exposed to an electron beam.

Yun, Hyejeong et. al., Korea | A series of repeated exposures to γ-irradiation with intervening outgrowth of survivors was used to develop radioresistant cultures of Moraxella osloensis, which have been recognized as potential pathogenic microorganisim.

Biju, K. et. al., India | Source-product irradiation geometry of radiation processing facilities are required to be designed to deliver prescribed dose to the product with an acceptable ‘dose uniformity ratio'. This paper presents the Monte Carlo study of the distribution of energy and dose in the product stack of standard size proposed by a private sector entrepreneur in India at the design stage.

Peimel-Stuglik, Zofia et. al., Poland | According to ISO/ASTM 51607:2004(E) the absorbed dose range of this system is between 1 and 105Gy, the dose rate is up to 5x107 Gy s-1 and the acceptable radiation energy for photons and electrons is between 0,1 and 28 MeV. 

Peimel-Stuglik, Zofia et. al., Poland |  It is commonly accepted that technological dosimeters should be cheap, non-toxic and with energy absorption characteristics similar as for organic matter. A polycrystalline sucrose (saccharose, C12H22O11) and also water solutions of sucrose fulfill all these demands.

Kairiyama, E., et. al., Argentina | Bioburden testing is a fundamental and important tool to evaluate the microbial quality of tissue allograph previous to submit final sterilisation. Frozen preserved morsellised bones of 77 batches from 3 tissue banks were analyzed to define the sterilisation. Even though they are procured and processed carefully, microbial contaminations occur. So a final sterilisation is necessary to reach a SAL of 10-6.

Kairiyama, E., et. al. Argentina | Skin bank facility is indispensable for burn care. In Argentina, the first human skin bank was established in 1989; later, 2 more banks were established in 1998 and 2002. The 3 banks preserve their processed cadaveric skin in frozen condition and use final gamma radiation sterilization since 1993.

Horak, Celina et. al, Argentina | The radiation sterilization has been carried out in our institution since 1968, using a Gammacell 220 (Northion). In 1970, a Cobalt 60 radiation facility was built with national technology.

Tabassum, Safia et. al. Pakistan | Spectrophotometric evaluation of aqueous solution of Acid Fuchsin (AF) as possible chemical dosimeter was carried out. A 5.0 x 10-5 M solution of AF was irradiated by gamma rays by a cobalt-60 radiation source and absorption spectra before irradiation and after irradiation was recorded.

Membership of RPSMUG | Since 2001 the Radiation Process Simulation and Modeling User Group (RPSMUG) has actively sought benchmark simulations and measurements that would provide both scientific and industrial processing end-users with a platform for comparison of mathematical models and simulations to photon and electron-based irradiation systems.

Murphy, M.K. et. al., USA | This paper describes performance testing results for the infrared fluorescence component of the Sunna Model γ dosimeter.

Desrosiers, M.F. et. al., USA | Dosimetric quality control plays a central role in the routine operation of a radiation processing facility. It is important that this dosimetry be suitably accurate and traceable to a national primary standard. The best and most versatile transfer dosimetry system is based on Electron Paramagnetic Resonance (EPR) measurements of the amino acid alanine.

Portugal, Luis et. al. | In December 2003 the irradiator of the Portuguese 60Co irradiation facility, UTR, was replenished. Eighteen new sources were loaded and the older ones (156) were rearranged. The result was an irradiator with about 10.2 PBq of total activity. The purpose of this work is to perform dosimetric studies inside the irradiation room of a 60Co irradiation facility, particularly, the flux and energy deposition distributions.

Kaluska, I. et. al., Poland | Investigation of boundary anomalies for an absorbed dose of an electron beam (EB) in multi-layer targets was carried out both by computer simulation and with film dosimetry. Multi-layer target in form of stack consists of a set of plates made of an arbitrary materials interleaved with dosimetric films with/without packing box was irradiated with scanned 10 MeV EB on moving conveyer.

Kaluska, I. et. al., Poland | Authors have developed the computer technology for simulation of problem tasks in radiation sterilization process in accordance with Method 1, Standard ISO 11137. The technology was realized on the base of the RT-Office modules for modeling by Monte Carlo method of an absorbed dose in an irradiated heterogeneous targets with electron beam (EB), X-ray and gamma-ray and specialized software ModeSAL.

Kaluska, Iwona et. al. Poland | Radiation sterilization facility to be recognized on the market as a reliable organization should established a complete quality management system.

Desrosiers, M.F., et. al., USA | As the response of all high dose range dosimeters are temperature dependent, the estimation of irradiation temperature and the subsequent correction via the temperature coefficient can be a significant source of error in industrial dosimetry. To date, NIST publications of alanine dosimeter temperature coefficient studies have not exceeded 50 °C for the irradiation temperature.